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Categorical data were analyzed using chi-square tests

Raw reads in fastq format were firstly processed using fastp [41], and low-quality reads were removed to yield clean reads

Schattenberg 6 , (1)Global Liver Institute, Washington, DC, USA, (2)Arizona Liver Health, Phoenix, AZ, (3)Boehringer Ingelheim International Gmbh, Ingelheim, Germany, (4)UCL Institute for Liver and Digestive Health, London, UK, (5)Asociacin Catalana De Pacientes Hepticos (ASSCAT), Barcelona, Spain, (6)Metabolic Liver Research Program, I