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DAMPs can not only bind to pattern recognition receptors (PRR) to subsequently promote adaptive immunity by inducing DC activation, but can also enhance adaptive immune responses by affecting the presentation of antigens associated with dying cells, promoting phagocytic action ( eat-me signaling, e.g., calreticulin), and facilitating antigen extraction and processing ( present-me signaling, e.g., F-actin or HMGB1) (111, 115, 117)

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