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On the other hand, HO-1 overexpression causes the accumulation of intracellular iron, promotes lipid peroxidation and triggers ferroptotic cell death (61,72,73)

doi: 10.1016/j.epsc.2019.101297

NOX-4 has been found to be involved in inflammation in diabetes and its deletion resulted in the downregulation of Nuclear factor-kappa B (NF-B) signaling, an important mediator of inflammation (Jha et al