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[] METTL4 is localized to mitochondria, preferentially methylates promoter regions of mtDNA, and disrupts assembly of the transcription initiation complex, leading to transcriptional stalling, impaired electron transport chain (ETC) genes expression, mitochondrial respiratory deficiency, and ultimately HF

Of these must-haves, only four are fat-soluble, meaning the body can store them within the fat cells when taken and/or consumed in excess

There are clinic-reported observations and case-series-level reports, of variable quality and almost universal commercial interest

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