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They also indicate that peripheral PRLM signatures may serve as clinically relevant biomarkers for assessing disease activity and guiding patient stratification

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

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45,51 An open to closed conformational change upon substrate binding was noted for CntL and involves the partially disordered interdomain linker in the CntLSAM binary complex becoming an ordered -helix in the CntLMTAxNA ternary complex