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However, APAP in high doses leads to hepatotoxicity, which is recognized as a major cause of acute liver failure 1

Others showed that accumulation of A-induced oxidative stress in APOE4 leads to the deregulation of the TP53 gene, and in addition to its role in cancer p53 protein (encoded by a TP53 gene) can be involved in cell death in AD patients, with upregulation at the early stages of the disease and downregulation during neurodegeneration (445)

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J.LengY.et al