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Chronic hypoxia for 7 or 14 d, but not 1 or 3 d, resulted in alpha-synuclein hyperphosphorylation at serine129 (-Syn p-S129) and protein aggregation, hippocampal neurodegeneration, and cognitive deficits, whereas the latter could be prevented by alpha-synuclein knockdown or an administered short peptide competing at -Syn S129

Concluso cientfica atual: composto experimental: Segundo a medicina baseada em evidncias, o BPC-157 deve ser tratado como um composto experimental, cujo uso clnico no recomendado fora de protocolos de pesquisa, devido falta de dados humanos consistentes sobre segurana e eficcia