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Cell Reports (2018) 10.1016/j.celrep.2018.05.054 Follow-up study showing that p53 mutations (common in cancer cells) confer resistance to FOXO4-DRI, highlighting the p53-dependent mechanism and the importance of functional p53 for the senolytic effect

Timeline estimates are based on reported outcomes in research settings and will vary between individuals

Senolytic therapies are typically pulsed short treatment courses with extended rest periods because senescent cell accumulation takes months to years