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30 The reduced folate carrier is a secondary mechanism which transports reduced folates, such as folinic acid, across the bloodbrain barrier, although high serum concentrations are required since the reduced folate carrier has a lower affinity for folate (i.e., micromolar concentrations) than the FR (i.e., nanomolar concentrations

In contrast, studies involving conditions such as schizophrenia, osteoarthritis, migraine, and functional gastrointestinal disorders were grouped under Non-metabolic chronic conditions, due to their distinct primary pathophysiological pathways, which do not centrally involve metabolic dysregulation

J Intern Med 290(4):826854