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Variation in glucocorticoid sensitivity and the relation with obesity

Activation of Nrf2-mediated gene expression in astrocytes, either via overexpression, pharmacological activation or activation by stressors such as oxidative stress or brief ischaemia confers non-cell-autonomous protection to surrounding neurons in a variety of models, including rodent models of neurodegenerative disease, as well as human stem cell-derived neuron-astrocyte systems 29,31,33

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