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Gabriella Clemente , Chris Rudnicky, Nadira Robinson-Burton, Jimmy Presto, David Lucente, Natalia Lattanzio, Puneet Mahal, Robert Gardner, Giorgio Ascoli, Theodore Dumas

The balance of the different CRP isoforms, monomeric (mCRP) or native pentameric (nCRP) within the plaque determines the preponderance of a proinflammatory or anti-inflammatory effect, respectively (165)

The authors reported that BPC 157 alone (without carrier) ameliorates healing of tendon and bone in the experimental rat model, with macroscopic, microscopic, and biomechanical assessments showing recovery of the tendon-to-bone unit that was not observed in untreated controls [3]

This not only enhances their inflammatory potential but also affects antigen processing, glutathionylation of signaling proteins, and interactions with resident CNS cells such as microglia and astrocytes (Federici et al., 2024)