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These authors have found lower levels of this adipokine in obese patients with type 2 diabetes mellitus

Removal of breast cancer cells from extracellular matrix (ECM) and local invasion and migration initiation: Disruption of the connection of the cell to ECM through cellular adhesion proteins such as integrins, resulting in the dissociation of cancer cells from adjacent cells and the basement membrane, describes how metastasis begins (118)

PMID: 28052884

The tattoo artist had used black ink instead of brown, making the freckles look very unnatural and dark, especially for a fair-skinned blonde (whose natural freckles would likely be much more reddish-brown)