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MCI was defined by clinical and imaging criteria: decreased level of consciousness, anisocoria, death or need for decompressive craniectomy, together with midline shift 6 mm, or infarction of more than 50% of the MCA territory

Xue K, Ruan L, Hu J, Fu Z, Tian D, Zou W

Endurance training enhances BDNF release from the human brain

Though further large-scale studies are needed, the early evidence supporting peptides and supplements is compelling, especially when these tools are used in conjunction with evidence-based treatments such as behavioral therapy and medication-assisted treatment