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Miss Frizzle in The Magic School Bus is a bit young, but otherwise fits this trope quite well

(2022) found that BBR modulates the GM and inhibits the initiation of the TLR4 signaling pathway, as well as the release of the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and its cytokines

Importantly, we identified a second nuclear export signal (NES2) within the founder sequence that is unique to Dp71f, thereby determining its efficient nuclear export and making its passage through the nucleus only transient