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Of enzymes that converts epoxyeicosatrienoic acids (EETs) to DHETs, the levels of microsomal epoxide hydrolase (EPHX1) positively correlated with fibrosis stage, but not soluble epoxide hydrolase (EPHX2)

Nevertheless, the observed occipital depletion aligns with broader evidence of redox imbalance and impaired mitochondrial function in depressive disorders

At the mechanistic level, environmental pollutants first increase intestinal permeability, allowing bacteria and their products to cross the intestinal barrier and activate the immune system, triggering chronic inflammation [230, 231]