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Prostaglandin E2 (PGE2), as a key immunosuppressive mediator, can suppress the activity of CTLs [92], dendritic cells [91], and NK cells [93], thereby interfering with anti-cancer immune responses

Not getting enough B12 can disrupt the autonomic nervous system, which controls functions like sweating

Bacterial labyrinthitis, especially when caused by invasive organisms such as Streptococcus pneumoniae or Haemophilus influenzae type B (Dodge et al., 1986) is devastating to the delicate tissue of the inner ear, and immunization against these pathogens provides significant protection (Schuchat et al., 1997)

Waste removal also slows and irritation can linger