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While some retrospective studies suggest that metformin may confer a survival benefit for diabetic patients with solid tumors, including PDAC, randomized controlled trials have not found significant benefits for PDAC patients when metformin is combined with gemcitabine [109, 113]

Statistics All statistical data were generated using the GraphPad Prism software package (GraphPad Software version 8 Inc., La Jolla, CA, USA)

I., Sinitsyn, D

Therefore, further investigation with a larger cohort of patients with chronic inflammation is necessary to gain a deeper understanding of the relationship between SARS-CoV-2 infection and the development of fibrosis