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It was also reported that microglia are capable of removing incorrectly deposited myelin directly from the axon, contributing to the refinement of myelin sheaths, as shown in zebrafish and mice during development (Hughes and Appel, 2020

Of note, colistin has been shown to exert tremendous side effects causing renal and neurological toxicity with higher cumulative doses, therefore limiting its effective in vivo application (131)

This minimally invasive method allows the therapeutic ingredients to reach directly into the deeper layers of the skin, where melanin production takes place and thus ensures the best possible absorption and effectiveness