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Gilead said the company will work with insurers, health care systems and other payers with the goal of ensuring broad insurance coverage for Yeztugo. Out-of-pocket costs for uninsured patients who take Truvada and Descovy, which Gilead also markets, can range from $22,000 to $30,000 a year, according to an analysis by GoodRx, which provides pharmacy drug pricing information

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The liver also plays a role in the enterohepatic circulationa recycling process where B12 is secreted in bile and reabsorbed in the intestinewhich may be disrupted in advanced disease