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Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress

While international interest is increasing, most patent applications are still in the early stages, and have not progressed significantly toward investigational new drug (IND) development or clinical applications

There are three isoforms of the SOD family and they all used a transition metal at their active site

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