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The digestive system breaks them down before meaningful amounts reach circulation

10.1007/s11255-011-9969-y Int Urol Nephrol

CNS Drugs 34:827839 Eap CB, Buclin T, Baumann P (2002) Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence

"Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney"