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This can be achieved by introducing biocompatible molecules on their surface [14, 15, 58, 159], and developing new and better synthesis methods, such as the use of green chemistry to produce biogenic NPs

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To obtain urea in mmol/L divide urea nitrogen in mg/dL by 2.8 or urea in mg/dL by 6.0.]) as [59]: The effective blood osmolality, known colloquially as blood tonicity, is a further clinically significant entity, which denotes the concentration of solutes impermeable to cell membranes (sodium, glucose [Glucose is a unique solute because, at normal concentrations in blood, it is actively taken up by cells and therefore acts as an ineffective solute, but under conditions of impaired cellular uptake (like diabetes mellitus) it becomes an effective extracellular solute.], mannitol) and are therefore restricted to the extracellular compartment (osmoreceptors sense effective blood osmolality rather than the total blood osmolality)