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Key variables in study design include: Route of Administration: Will the compound be studied via systemic injection (subcutaneous, intramuscular) or a more localized injection near the site of injury

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Accumulation Ketorolac tromethamine administered as an IV bolus, every 6 hours for 5 days to healthy subjects (n = 13), showed no significant difference in C max on Day 1 and Day 5

Homocysteine and methylmalonic acid levels in the blood are stronger indicators of proper vitamin B12 activity than homocysteine