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Description

The Increlex (mecasermin) FDA label, which covers native rhIGF-1 in pediatric severe primary IGFD, is the closest human reference and informs the contraindications below

Additionally, if low libido persists despite adjustments to TRT dosage, changes in lifestyle factors, and addressing psychological factors, it may be necessary to explore other treatment options

In supervised studies with the GHRH analog tesamorelin, IGF-1 stayed within the age-normal range, and insulin-stimulated glucose uptake was preserved (Stanley et al., 2011)