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A study from 2016 on 21 human patients diagnosed with a high-grade prostatic intraepithelial neoplasia (PIN), a condition associated with higher prostate cancer risk, found that 12 months of treatment with a DIM-based therapy called Infemin yielded statistically significant results.15 16 Around half (45.5%) of the treated patients experienced a complete regression of PIN, while no regression was seen in patients in the placebo group.15 A separate 2016 study on BR-DIM supplementation for prostate cancer patients reported similar biomarker-related findings.17 A group of 28 men with localized prostate cancer were given BR-DIM at a daily dose of 450mg for two weeks

CHAC1 regulates this pathway by specifically inhibiting the S1 cleavage of Notch