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Since the main physiological role of DME and DT is to dispose of various endogenous compounds, some studies in recent years have proposed to characterize the activity of DME and DT by detecting changes in the levels of these biomarkers, which has been well applied in the early DDI studies of drug discovery [174]

EMBO Rep 7 , 11 (2006)

The ideal dosage and frequency of intramuscular vitamin B12 injections to treat hemolytic anemia linked with vitamin B12 deficiency are yet to be definitively established

Reports have linked the concentration of 8-oxo-7,8-dihydro-20-deoxyguanosine (8-oxodG) in the urine of mothers at 12 weeks of gestation with an increased risk of IUGR (Potdar et al., 2009), indicating that oxidative stress may occur before the symptoms of IUGR are noticeable