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Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys

At the oxidative stress level, excessive generation of ROS and antioxidant system imbalance have been observed to not only directly damage intestinal mucosal cells but also to influence immune cell differentiation and barrier repair through modulation of signaling pathways, thereby creating a vicious cycle of inflammatory progression [12, 29]

Folate supplementation in high-fructose-fed rats increased the phosphorylation levels of AMPK and LKB1 and inhibited the phosphorylation of ACCs in the liver, then significantly increases hepatic SAMe, inhibits hepatic lipogenesis and thus ameliorates hepatic steatosis (90)

Given the complexity of targeting neural receptors, future studies in our lab will aim at examining whether long-term peripheral administration of MTII, a more translational approach for humans, would yield similar physiological responses