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Description

Therapeutic intervention may involve the use of renin-angiotensin system (RAS) blockers to inhibit the vasoconstrictive effect of angiotensin II at the vas efferens or sodium-glucose co-transporter-2 (SGLT2) inhibitors, constricting the afferent arteriole, thereby reducing the burden of excessively filtered molecules in the proximal tubule (e.g., albumin, glucose and phosphate) [34]