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For instance, oedematous SAM is associated with secondary immune deficiency, intestinal dysbiosis, epithelial barrier disruption, and growth faltering, all of which exacerbate inflammation and worsen immune dysfunction (appendix p

Ethics declarations Competing interests J.M.R has been a paid consultant to Aquestive Pharmaceuticals, Danone Nutricia, Mallinckrodt, Eisai Pharma and Zogenix, and has served on the Scientific Advisory Board of The Charlie Foundation for Ketogenic Therapies (Santa Monica, CA, USA)

Furthermore, the inhibition of proteolytic enzymes was suggested to promote the activation of apoptotic events in MCF-7 breast cancer cells (228)

In contrast, the anchorage of OHC SC to TM pushes a wider tilting of TM over OHC