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2012 May;13(5):291-6

Its still a very active area of research

The results indicated that scaffold implantation helps maintain intervertebral disc height, reduces NP moisture loss, and partially restores the biomechanical function of the IVD ( In vitro and in vivo experiments demonstrated that this composite scaffold enhanced osteogenic differentiation, promoted angiogenesis, and accelerated abnormal NP degeneration, making it suitable for lumbar interbody fusion (Zhang et al., 2025b)

This inhibitory effect stems from ribosome halting when the modified codon occupies the ribosomal A-site which is consistent with the increased frequency of Nm occurrence in the first position of the codon, where this modification has the least inhibitory effect