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Full normalization is more likely when underlying contributors like excess body fat, poor sleep, inflammatory diets, and chronic stress are addressed alongside treatment

In the study Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin , it was found that providing calcium supplementation to people taking metformin, was able to help prevent metformin-induced vitamin B12 deficiency

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Hydroxocobalamin 1mg intramuscular injections are prescription-only medicines in the UK, indicated for confirmed B12 deficiency or malabsorption conditions such as pernicious anaemia