napqi and glutathione A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N-acetyl-p-benzoquinone imine with deoxyguanosine Problem 2 n acetyl para

Problem 2 n acetyl para benzoquinone napqi is an oxidized 5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. Biopharmaceutics and Drug Disposition Pharmacology Journal Wiley Online Library A crossomics analysis of acetaminopheninduced hepatotoxicity in rat liver Sumida 2015 Rapid Communications in Mass Spectrometry Wiley Online Library

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