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These include mGlu5 antagonists (fenobam), AMPA receptors (ampakines), and NMDA receptor inhibitors such as memantine, amantadine, and acamprosate [112, 145]

In PAH, TGF-1 is upregulated, particularly in PASMCs, with a stronger stimulatory effect observed in PAH PASMCs than in patients with chronic obstructive pulmonary disease [56, 95, 96]