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Elevated MMA is a specific marker of vitamin B12 deficiency while Hcy [homocysteine] rises in both vitamin B12 and folate deficiencies. So, metabolic B12 deficiency is strictly defined by elevation of MMA levels or by elevation of Hcy in folate-replete individuals, that is, in those getting enough folate

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Others develop pins and needles or memory lapses

Autofluorescence detecting lipofuscin accumulation (oxidative stress marker in AMD)