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Patients addressing acute oxidative load recovery from illness, heavy travel, post-surgical support may run a higher-frequency loading protocol up front

10.1113/EP091707 161 KovacevicA.MavrosY.HeiszJ

doi:10.1186/2045-3701-4-29 Seale P (2015) Transcriptional regulatory circuits controlling brown fat development and activation

Unlike other organelles such as mitochondria, where an abundance of reduced glutathione (GSH) preserves a reductive environment, the ER requires an oxidizing milieu to facilitate the formation of disulfide bonds critical for protein structural integrity