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Gut microbiota orchestrates GLP-1 secretion through metabolite-mediated mechanisms: firstly, SCFAs promote GLP-1 release via dual pathways: one is to activate the cell signaling pathway by binding to the FFAR2/FFAR3 receptor, which is impaired in FFAR2-deficient mice and shows decreased GLP-1 levels and glucose tolerance abnormalities (Tolhurst et al., 2012)

The peptide earned its name from initial observations that its injection could induce slow-wave sleep (delta sleep) in animals, leading to extensive investigation of its potential as a sleep-promoting agent and its broader physiological roles

PMID 15094084