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Targeting active molecules to the mitochondria is likely to improve their effectiveness against oxidative insult and hence be beneficial for FRDA patients due to reduced off-target therapy, increased specificity and lower therapeutic dosage required of the targeted chelator (Reelfs, et al., 2019

The protocol first involved collating various kinetic values from literature, and assigning each value a weight to represent their plausibility, based on the organism, enzyme and conditions under which the kinetic parameter was measured

Data were collected from parents through a self-administered questionnaire and from study subjects through a face-to-face interview by trained data collectors

Ethics approval and consent to participate The "Guide for the Care and Use of Laboratory Animals" and the Ethical Committees approval of the Faculty of Science, Suez University, Suez, Egypt, for the use of animal subjects guidelines were followed in all experimental procedures