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doi:10.1016/j.metabol.2011.03.002 Forrest KY, Stuhldreher WL

Tonic extracellular glutamate and ischaemia

Mao found that treating cancer cells with GPX4 inhibitors resulted in acute depletion of N-carbamyl-L-aspartate (C-ASP, a pyrimidine biosynthesis intermediate), accompanied by accumulation of uridine, which could be inhibited by fer-1, a ferroptosis inhibitor [18]

The identity of NFT derivatives and/or reactive oxygen species interacting with the Nrf2-Keap1 complex were not identified in the course of the present work, but will be investigated in future studies