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The observed decrease in GPx4 activity after TBI, along with these findings, suggests that the System Xc/GSH/GPX4 pathway plays an important role in the activation of ferroptosis following TBI (Figure 3D

The FN III subunit features a binding domain known as FN III 12-14 , which contains positively charged amino acids, lysine, and arginine, facilitating interactions with multiple bioactive proteins, including TGF-, BMP-2, BMP-6, BMP-7, PDGF-BB, and HGF

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High-dose vitamin E (above 800 IU/day) has shown additive hepatotoxic potential in rodent models [14]