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The small molecule compound RSL3 can also bind to the Sec in the active site of GPX4, directly inhibiting the antioxidant activity of GPX4 and inducing ferroptosis (Yang et al., 2014

The applicant followed the order of operations described in the following table and calculated a final inflated average case-weighted standardized charge per case of $133,657, which exceeded the average case-weighted threshold amount of $93,649