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2.2 Folate Receptor Alpha, Autoantibodies & Cerebral Folate Deficiency The folate receptor alpha (FR) is the primary transporter of 5-methyltetrahydrofolate (5-MTHF) across the bloodbrain barrier

Thus, as depicted in Scheme 1, hydrogen bonding interaction between neighboring COOH groups overcome the interparticle repulsive force (electrostatic and/or steric repulsion) and draw AuNPs to aggregate

We showed that our model accurately reproduces published clinical and experimental data on the dose-dependent time course of acetaminophen in the plasma, the accumulation of acetaminophen and its metabolites in the urine, and the depletion of glutathione caused by conjugation with the toxic product

Calmes et al., 2017)